Search Result

Search Results for " pancreatic lipase "

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T63015	Pancreatic lipase/Carboxylesterase 1-IN-1
	Pancreatic lipase/Carboxylesterase 1-IN-1 (Compound 39) is a potent, dual inhibitor of pancreatic lipase (PL) and human carboxylesterase 1A (hCES1A), acting on PL (IC50: 2.13 μM) and hCES1A (IC50: 0.055 μM).
T3283	Cetilistat	ATL-962	Lipid
	Cetilistat (ATL-962) is a novel inhibitor of pancreatic lipase being developed by Alizyme for the treatment of obesity and associated co-morbidities, including type 2 diabetes.		Lipid
T39189	3,4,5-Trihydroxycinnamic acid decyl ester
	3,4,5-Trihydroxycinnamic acid decyl ester, an effective inhibitor of lipid absorption and accumulation, exhibits anti-obesity properties. Additionally, this compound acts as a pancreatic lipase inhibitor, with an EC 50 o...
T77668	HPL-IN-1		Others
	hPL-IN-1 is a potent reversible pancreatic lipase (PL) inhibitor (IC50=1.86 μM) that can be used to study obesity-related diseases.		Others
T77679	HPL-IN-2		Others
	hPL-IN-2 is a potent, reversible and non-competitive inhibitor of Pancreatic lipase (IC50: 1.63 μM) that can be used to investigate obesity-related diseases.		Others
T41160	Lalistat 2		Lipase
	Lalistat 2 is a selective inhibitor of lysosomal acid lipase with IC50 of 152 nM and exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein lipase (up to 10 μM).		Lipase
T10768	Cetilistat impurity 1		Others
	Cetilistat impurity 1 is an impurity of Cetilistat. Cetilistat is an inhibitor of pancreatic lipase. Cetilistat inhibits rat and human pancreatic lipase activity (IC50s: 54.8 nM and 5.95 nM).		Others
T70882	Orlistat-d3
	Orlistat-d3 is intended for use as an internal standard for the quantification of orlistat by GC- or LC-MS. Orlistat is a digestive lipase inhibitor. It inhibits diacylglycerol lipase α (DAGLα), DAGLβ, α/β-hydrolase doma...
T35979	Benastatin C
	Benastatin C is a polyketide synthase-derived benastatin that has been found inStreptomycesand has diverse biological activities.1,2It inhibits glutathione S-transferase (GST; IC50= 24 μg/ml for the rat liver enzyme).2Be...
T36864	GRP (human) (trifluoroacetate salt)
	Gastrin-releasing peptide (GRP) is a neuropeptide that stimulates gastrin release. It binds to (Ki = 300 nM) and stimulates amylase secretion in rat pancreatic AR42J cells (EC50 = 0.3 nM). GRP increases proliferation of ...

Compounds

Pancreatic lipase/Carboxylesterase 1-IN-1

3,4,5-Trihydroxycinnamic acid decyl ester

Cetilistat impurity 1

GRP (human) (trifluoroacetate salt)

T36864

Synonym:

Target:

Cat No.	Product Name	Synonyms	Targets
T4S1312	Gypsogenin-3-O-glucuronide	Methyl gypsogenin 3-O-beta-D-glucuronopy	Others
	1. Gypsogenin-3-O-glucuronide (Methyl gypsogenin 3-O-beta-D-glucuronopy) shows inhibitory activity toward pancreatic lipase with IC5 value of .29 mM, and the free carboxylic acid groups in position 28 within its chemical...		Others
T5707	3-O-Methylgalangin	3-Methylgalangin,GALANGIN-3-METHYLETHER	Antibacterial
	3-O-Methylgalangin (GALANGIN-3-METHYLETHER) has antibacterial activity, it has inhibitory effects on Pseudomonas aeruginosa. GALANGIN-3-METHYLETHER has hypolipidemic activity, the action is due to the inhibition of pancr...		Antibacterial
T2840	Phloracetophenone	2,4,6-trihydroxyacetophenone,1-(2,4,6-Trihydroxyphenyl)ethanone	Others , P450 , Antibacterial , Antibiotic
	Phloracetophenone (1-(2,4,6-Trihydroxyphenyl)ethanone) has antiobesity and hypolipidemic effects, may be partly mediated by delaying the intestinal absorption of dietary fat by inhibiting pancreatic lipase activity.		Others , P450 , Antibacterial , Antibiotic
T5S1389	Escin IB		5-HT Receptor , NO Synthase
	Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to act through central dopamine2 receptor, which in turn causes...		5-HT Receptor , NO Synthase
T3779	Crocin II	Crocin 2,Crocetin gentiobiosylglucosyl ester,Tricrocin,Crocin B	Caspase , COX , NO Synthase
	Crocin II (Crocetin gentiobiosylglucosyl ester) has anti-inflammatory and anti-apoptotic effects against gastric ischemia-reperfusion injury in rats, the effect of crocin is mainly mediated by reducing the protein expres...		Caspase , COX , NO Synthase
T40464	Neotheaflavin
	Neotheaflavin, from black tea, inhibits pancreatic lipase.
T83206	Acanthopanaxoside A
	Acanthopanaxoside A, a triterpenoid saponin, exhibits inhibitory activity against pancreatic lipase [1].
TN3118	5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA)		Others
	5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA) is a pancreatic lipase inhibitor, it shows antihyperlipidemic activity.		Others
T82712	Ciwujianoside C4
	Ciwujianoside C4, a saponin derivative, has been demonstrated to increase pancreatic lipase activity in vitro [1].
T82713	Ciwujianoside C1
	Ciwujianoside C1, a saponin derived from the leaves of Acanthopanax senticosus, exhibits in vitro inhibition of pancreatic lipase activity [1].
T75645	Echitamine chloride
	Echitamine chloride, the predominant monoterpene indole alkaloid found in Alstonia scholaris, exhibits significant anti-tumor activity by inducing DNA fragmentation and apoptosis. Furthermore, it effectively inhibits pan...
T83308	5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl
	5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl (compound 8), extracted from Dendrobium infundibulum (D. infundibulum), exhibits no inhibitory effects on α-glucosidase and pancreatic lipase [1].
TN5463	Leachianone G
	Leachianone G exhibits significant antioxidant potentials in the ABTS, ONOO(-), and total ROS assays, it also shows inhibitory activities against pancreatic lipase, it may be used as drug candidate to control obesity. Le...
TN4580	Morachalcone A		Tyrosinase
	Morachalcone A displays significant tyrosinase inhibitory activity (IC50, 0.013 uM); it also exerts strong pancreatic lipase inhibition with IC 50 value of 6.2 uM. Morachalcone A exhibits neuroprotective effects on HT22-...		Tyrosinase
TN5682	2,6,4'-Trihydroxy-4-methoxybenzophenone
	2,6,4'-Trihydroxy-4-methoxybenzophenone shows weak inhibitory activity of testosterone 5alpha-reductase, it also shows significant inhibition of pancreatic lipase activity. 2,6,4'-Trihydroxy-4-methoxybenzophenone has neu...

Natural Products

Gypsogenin-3-O-glucuronide

T4S1312

Synonym: Methyl gypsogenin 3-O-beta-D-glucuronopy

Target: Others

3-O-Methylgalangin

T5707

Synonym: 3-Methylgalangin,GALANGIN-3-METHYLETHER

Target: Antibacterial

Phloracetophenone

T2840

Synonym: 2,4,6-trihydroxyacetophenone,1-(2,4,6-Trihydroxyphenyl)ethanone

Target: Others, P450, Antibacterial, Antibiotic

Escin IB

T5S1389

Synonym:

Target: 5-HT Receptor, NO Synthase

Crocin II

T3779

Synonym: Crocin 2,Crocetin gentiobiosylglucosyl ester,Tricrocin,Crocin B

Target: Caspase, COX, NO Synthase

5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA)

5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl

2,6,4'-Trihydroxy-4-methoxybenzophenone

TN5682

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-00252	PNLIPRP1 Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	PNLIPRP1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52 kDa and the accession number is P54316.
TMPY-03222	PNLIP Protein, Human, Recombinant (His)	Human	HEK293 Cells
	PNLIP is an enzyme that belongs to the lipase family. Secreted from the pancreas, PNLIP is the primary lipase that hydrolyzes dietary fat molecules in the human digestive system, converting triglyceride substrates found ...
TMPY-03182	PLRP2 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Galactolipase, also known as PNLIPRP2, is a lipase with broad substrate specificity. It can hydrolyze both phospholipids and galactolipids. Galactolipase acts preferentially on monoglycerides, phospholipids and galactoli...
TMPY-03808	PNLIPRP1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	PNLIPRP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.4 kDa and the accession number is AAH25784.1.
TMPY-03353	CEL Protein, Mouse, Recombinant (His)	Mouse	Baculovirus Insect Cells
	CEL-maturity onset diabetes of the young (MODY), diabetes with pancreatic lipomatosis and exocrine dysfunction, is due to dominant frameshift mutations in the acinar cell carboxyl ester lipase gene (CEL). Bile-salt activ...